Natural Products

Natural products offer a vast source of chemical diversity and yield unusual and unexpected lead structures. As such small molecules produced in this way have been designed by nature to interact with macromolecules (Proteins, DNA etc) and thus modulate the function of such macromolecules. Natural products can derive a wide portfolio of lead structures that shall drive next generation drug discovery. It also provides an opportunity to explore poly herbal formulations that can become potential source for Phytopharmaceuticals, Cosmeceuticals and Food Supplements.

Our Natural Products research focuses on two major areas

Natural Products Drug Discovery
Formulations Research

Compound Libraries

The bioactive compounds are isolated from the raw material by different methods, such as extraction, distillation, separation and analysis. The compounds are isolated and maintained at more than 95% purity. The phytochemical extraction involves homogenization, vaccum filtration, solvent evaporation, lipophilization and involves utilization of various analytical instruments for the same.

Knowledge in isolation, purification, and structure elucidation of natural products, and our current collection of a variety of pure natural product samples provides a foundation for building natural product based combinatorial libraries, as well as for offering services to identify a minor component in a given sample, whether it is an active compound, a metabolite, or an impurity. Our collection comprises natural compounds isolated from plants, microorganisms, marine species etc.

High throughput screening using a 96-well plate is used to generate a large number of low concentration plates for screening. Sristibio has all necessary facilities and equipment to isolate and chemically identify biologically active components. Additionally, identification and chemical synthesis can be provided. In addition we provide

Accurate identification of species names
Precise information regarding location of samples
Resupply with the aid of a large network of collectors

Plants

Srsiti constructs libraries to target gene families, protein targets, to expand the chemical diversity of the company’s compound collection. The database contains approximately 1000 chemical compounds derived from various plant sources including terpenes, saponins, flavonoids, Sterols etc. Our compound libraries from plant sources includes

Diverse sets of biologically relevant small molecule
Core scaffold of an individual natural product
Molecules with high ligand affinity and better specificity to biological targets
Diversity of scaffolds for the synthesis of natural compound-like libraries
Molecular diversity of structurally similar analogs
Valuable pharmacological probes to help target various receptros

Marine

Marine Compounds is a collection of bioactive metabolites of marine microorganisms and invertebrates. The current edition of the library covers more than 700 molecules which include alkaloids, diterpenes, eicosanoids, nucleosides, peptides, polycyclic ethers, toxins, sterols, sesquiterpenes, etc.

Marine habitat is considered to be a major source for potential drugs. The library serves as an important source for both biologists and chemists who look for potential pharmaceuticals. The library can be queried using simple & advanced search.

Screening

Screening is an approach to chemical synthesis that enables the creation of large numbers of organic compounds by linking chemical building blocks in all possible combinations, identify novel compounds with therapeutic and preventive efficacy against disease This approach to testing drug candidates is highly dependent on the quality of the initial library of compounds, and the intelligence used to select the initial lead candidates that guide the screening process. Our objective lies in devising computational approaches for testing the binding activity of extensive naturally occurring compound libraries prior to testing activity using ligand-binding approaches and assays.

We believe our drug discovery and development approach can significantly improve on the industry’s existing clinical attrition rates through our use of

Proprietary cheminformatics databases that relate chemical structure to compound development potential;
Multiple lead generation strategies including high throughput screening, virtual screening
A company-wide techniques that enables scientists to collect, analyze and share information across the organization

Supply

We supply compound source plates and assay plates containing compounds in 96-well micro plates for HTS. We plate the compounds in 96 well microplating in fixed amounts of DMSO solution for screening. We will also supply compounds in vials based on the request.

More than 100000 synthetic and natural compounds are available for screening anti-cancer, diabetes and anti-infective. We supply radio-labelled compound at the maximum possible purity. Our approach is to set up a fractionation scheme and to screen the fractions for the presence of bioactive properties. The following are the services offered.

Building Blocks

Our innovative technology platform and extensive expertise in biocatalysis enable us to build wide range of building block library. Our chemical building block library has been developed to support advanced combinatorial lead generation, lead optimization and medicinal chemistry programs. By developing tailor-made building blocks we can assist clients from early development to commercial stage.

All of our chemical building blocks undergo extensive quality control, and purity is guaranteed to be over 95%.

Supply

Building Blocks

All of our chemical building blocks undergo extensive quality control, and purity is guaranteed to be over 95%.

Focus

Cancer

Diabetes

Anti - Infectives

Cancer

Diabetes

Anti - Infectives

Licensing

We share expertise and offer consultancy in :

Good Agriculture practise for reliable source
Organic Certification
Process Technology with raw material screening and end product analysis
GMP standard guidance for manufacturing and Documentation
Formulation Technology
Technical training for Quality Management and Process
Documentation for Drug, Cosmetic and Nutraceuticals Licenses
Product registration / Documentation for overseas market
Clinical Validation
Scientific validation of herbal and the Indian Systems of medicine
Exploring new Herbs and Plants
Phytochemical and Phyto-pharmacological studies for lead finding in natural products from the great ancient treatise of India
Herbal therapeutics – Pharmacokinetics and utilization of Herbal drugs
Safety evaluation of Natural products
Technology transfer on Turnkey projects.

Research

Our Research and Development out fit has been carrying on Research and Development activities in various herbal formulation and has developed several formulations of Medicines, Cosmetic and Nutraceuticals.

Our mission is to be a primary manufacturer and supplier of active herbal (Indian system of medicines) pharmaceutical ingredients of the highest quality and purity to the traditional pharmaceutical and emerging phytopharmaceutical Industries.

Isolation, purification and standardization of various formulations derived from plants and other natural sources that can be incorporated into regulated, finished formulations, prescription and OTC products to be sold by clients.

Product Development

Our Integrated Product Development service delivery platform for product development helps in:

Identifying market segments of high value
Shortlisting an innovative proposition from either existing licenses or new license development in record time with a clearly marked up USP and offer value
Documentation and application of product license in the respective country’s regulatory compliances
Process Engineering and development of manufacturing and packaging requirements
Documentation of process engineering and packaging standards for compliance
Backward integrating supply of raw materials for production
Handholding on establishment of the manufacturing unit
Continuous handholding in terms of GMP, quality and production planning
Marketing Partnerships and support

Brands - Dr. Aloe

Dr.Aloe as a Nutritional Supplement assists the body in performing

The key function of boosting immune system due to the abundant presence of polysaccharides, a property exclusive to this plant.
It also contains amino acids, vitamins, minerals and enzymes.
It aids digestive system by improving absorption of nutrients.
It is a detoxifier and strengthens the nervous system.
Dr. Aloe is available in 500 ml. container.

Working Hours

Mon-Sat: 9:30 AM – 6:30 PM
Sunday: Closed

Ph: +91-40- 24045551
Fax: +91-40-24045552

Office

11-9-49, Suite 301, Ace Prime Krishna Ventures Road No: 1, Laxmi Nagar Colony, Kothapet, Hyderabad, Telangana – 500 060

contactus@orgavitaz.com